Integrating biomedic mechanism in sidhakarya meditation for the prevention of aortic aneurysm

Abstract

Aortic aneurysm remains a significant cardiovascular challenge characterized by the progressive weakening and excessive dilation of the aortic wall, which poses a high risk of spontaneous rupture. This degenerative pathology is primarily driven by uncontrolled oxidative stress and chronic inflammation that compromise the mechanical integrity of endothelial cells and elastin fibers. Despite rising global mortality, the condition’s asymptomatic nature often complicates primary prevention and homeostatic reinforcement efforts. This review aims to explain how multilevel cellular communication pathways contribute to aortic aneurysm pathogenesis and how these pathways are modulated by Sidhakarya meditation. This Balinese mind-body practice addresses vascular degradation through a three-stage neurophysiological transition—Preparation, Core, and Closing—that shifts the autonomic nervous system from sympathetic dominance to parasympathetic activity. Clinical evidence indicates that this intervention reduces Malondialdehyde (MDA) levels by 30% and lowers systemic blood pressure, effectively mitigating the hemodynamic shear stress associated with abnormal vessel dilation. By stabilizing the Hypothalamic-Pituitary-Adrenal (HPA) axis and enhancing heart rate variability, the protocol optimizes the aorta's elastic response and structural resilience. Ultimately, bridging indigenous spiritual wisdom with modern biomedical mechanisms offers a culturally resonant and evidence-based framework for sustainable cardiovascular prophylaxis.